Clinical significance of PD-L1 protein expression on tumor-associated macrophages in lung cancer
نویسندگان
چکیده
Introduction Tumor PD-L1 expression is associated with increased tumor-infiltrating lymphocytes (TILs) in diverse solid tumors, including lung cancer. In addition, PD-L1 upregulation in tumor and/or stromal immune cells has been associated with increased clinical benefit to PD-1/ PD-L1 axis blockers. The significance of PD-L1 expression in different immune cell subpopulations at the tumor microenvironment remains poorly understood. Here, we measured PD-L1 protein specifically in tumorassociated macrophages using objective methods and analyzed its clinical significance in human lung cancer.
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